- $1540
- Alomone
- 以色列
- ESD-601
- 2025年06月11日
- 见官方网站
- 见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
ESD-601
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
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- 靶点：
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- 抗体英文名：
Human proBDNF Deluxe Research Pack
- 抗体名：
Human proBDNF Deluxe Research Pack
- 规格：
13 Vials
Human proBDNF Deluxe Research Pack
All You Need for proBDNF ResearchCat #: ESD-601
13 Vials
Alomone Labs is pleased to offer the Human proBDNF Deluxe Research Pack (#ESD-601). The Research Pack contains all you need for human proBDNF research: Antibodies to proBDNF and its receptor, recombinant proteins and a conjugated recombinant protein, all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-proBDNF |
ANT-006 | 1 x 0.2 ml |
Anti-p75NTR (extracellular) |
ANT-007 | 1 x 0.2 ml |
Anti-proBDNF-ATTO-488 |
ANT-006-AG | 1 x 50 µl |
Anti-p75NTR (extracellular)-ATTO-550 |
ANT-007-AO | 1 x 50 µl |
Guinea pig Anti-proBDNF |
AGP-032 | 1 x 0.2 ml |
human proBDNF |
B-257 | 1 x 25 µg |
human proBDNF-Biotin |
B-256-B | 1 x 10 µg |
human proBDNF (cleavage resistant) |
B-256 | 1 x 5 µg |
Note A guinea pig polyclonal antibody (#AGP-032) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF) neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5).
All neurotrophins are synthesized as preproneurotrophin precursors that are subsequently processed within the intracellular transport pathway to yield proneurotrophins that are further processed to generate the mature form. The mature form of BDNF is a non-covalent stable homodimer that can be secreted in both constitutive and regulated pathways.
Until recently, the functional role of the neurotrophin prodomains were thought to include assistance in the correct folding of the mature protein and the sorting of the neurotrophins into the constitutive or regulated secretory pathway. However, a growing body of evidence suggests that the uncleaved proneurotrophin precursors can be secreted from cells and that they may mediate different biological functions.
The functional importance of the prodomain of BDNF was recently demonstrated in a study showing that a polymorphism that replaces valine for methionine at position 66 of the pro domain, is associated with memory defects and abnormal hippocampal function in humans. Another recent study showed that the regulated extracellular cleavage of proBDNF to mature BDNF by plasmin is necessary for establishing late-phase long-term potentiation (L-LTP) a process that involves long-lasting changes in the structure and function of hippocampal synapses. Finally, proBDNF was shown to be decreased in the brains of patients suffering from Alzheimer’s disease.
Mature BDNF binds to the specific tyrosine kinase receptor TrkB and to p75NTR, a member of the TNF receptor superfamily. proBDNF can similarly bind both receptors although it appears to have a greater affinity for the p75NTR receptor.
Human proBDNF Deluxe Research PackReferences
- Lee R. et al. (2001) Science 294,1945.
- Egan, M.F. et al. (2003) Cell 112, 257.
- Pang, P.T. et al. (2004) Science 306, 487.
- Michalski, B. et al. (2003) Mol. Brain Res. 111, 148.
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