Anti-CD274 Polyclonal Antibody

英文名称Rabbit CD274 Polyclonal Antibody别名B7-H;B7H1;PD-L1;PDCD1L1;PDCD1LG1;PDL1 
应用WB稀释比例WB1:500-1:2000交叉反应Human,Mouse蛋白分子量33kDaGene ID29126保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原Recombinant protein of human CD274性状Lyophilized or LiquidSwiss ProtQ9NZQ7克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.