All You Need for TRPV1 Channel Research
Cat #: ESD-300
12 Vials
Alomone Labs is pleased to offer the TRPV1 Channel Deluxe Research Pack (#ESD-300). The Research Pack contains all you need for TRPV1 research: Antibodies recognizing different domains of the channel, specific TRPV1 blockers and an activator, all in one economical package!
Compounds
Scientific Background
Related Products
Product Name
Cat #
Size
Anti-TRPV1
ACC-030
1 x 0.2 ml
Guinea pig Anti-TRPV1
AGP-118
1 x 0.2 ml
Anti-Rat TRPV1 (extracellular)
ACC-029
1 x 0.2 ml
Anti-Rat TRPV1 (extracellular)-ATTO-488
ACC-029-AG
1 x 50 µl
A-889425
A-195
1 x 10 mg
Capsaicin
C-125
1 x 250 mg
Resiniferatoxin
R-400
1 x 1 mg
SB-366791
S-180
1 x 25 mg
Note A Guinea pig polyclonal antibody (#AGP-118) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPC, TRPM, TRPA, TRPP, TRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.
The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3
TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6
TRPV1 Channel Deluxe Research PackReferences
Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.
Cesare, P. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7658.
Kim, J. et al. (2003) Nature 424, 81.
Ahern, G. P. et al. (2003) J. Biol. Chem. 278, 30429.
Ross, R.A. et al. (2003) Br. J. Pharmacol. 140, 790.