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- Alomone
- 以色列
- ESD-300
- 2025年07月16日
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- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
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- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
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- 适应物种：
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- 保质期：
6个月
- 抗原来源：
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- 目录编号：
ESD-300
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
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- 应用范围：
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- 浓度：
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- 靶点：
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- 抗体英文名：
TRPV1 Channel Deluxe Research Pack
- 抗体名：
TRPV1 Channel Deluxe Research Pack
- 规格：
12 Vials
TRPV1 Channel Deluxe Research Pack
All You Need for TRPV1 Channel ResearchCat #: ESD-300
12 Vials
Alomone Labs is pleased to offer the TRPV1 Channel Deluxe Research Pack (#ESD-300). The Research Pack contains all you need for TRPV1 research: Antibodies recognizing different domains of the channel, specific TRPV1 blockers and an activator, all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-TRPV1 |
ACC-030 | 1 x 0.2 ml |
Guinea pig Anti-TRPV1 |
AGP-118 | 1 x 0.2 ml |
Anti-Rat TRPV1 (extracellular) |
ACC-029 | 1 x 0.2 ml |
Anti-Rat TRPV1 (extracellular)-ATTO-488 |
ACC-029-AG | 1 x 50 µl |
A-889425 |
A-195 | 1 x 10 mg |
Capsaicin |
C-125 | 1 x 250 mg |
Resiniferatoxin |
R-400 | 1 x 1 mg |
SB-366791 |
S-180 | 1 x 25 mg |
Note A Guinea pig polyclonal antibody (#AGP-118) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPC, TRPM, TRPA, TRPP, TRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.
The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3
TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6
TRPV1 Channel Deluxe Research PackReferences
- Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.
- Cesare, P. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7658.
- Kim, J. et al. (2003) Nature 424, 81.
- Ahern, G. P. et al. (2003) J. Biol. Chem. 278, 30429.
- Ross, R.A. et al. (2003) Br. J. Pharmacol. 140, 790.
- Tominaga, M. et al. (1998) Neuron 21, 531.
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文献和实验Ion Channels in Analgesia Research
of stimuli that can cause pain. During the last decade, compelling evidence has been gathered on the role of the TRPV1 channel in inflammatory and neuropathic states. Activation of TRPV1 in nociceptive neurons results in the release
官方解读：我们如何感知温度和疼痛？这篇文章帮你看懂今年诺奖成果
现它们可以被一系列不同的温度激活。许多实验室通过使用缺乏这些新发现基因的基因操纵老鼠来进行研究，以研究这些通道在热感觉中的作用。David Julius 发现 TRPV1 是一项突破，它让我们了解了温度的差异是如何在神经系统中诱发电信号的。Research under pressure!虽然温度感觉的机制正在逐步展开，但机械刺激如何转化为我们的触觉和压力感仍不清楚。此前，研究人员在细菌中发现了机械传感器，但在脊椎动物中，触觉的潜在机制仍不清楚。Ardem Patapoutian 在美国加州拉霍亚的斯克
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