All You Need for NaV1.8 Channel Research
All You Need for NaV1.8 Channel Research
Cat #: ESD-003
11 Vials
Alomone Labs is pleased to offer the NaV1.8 Channel Deluxe Research Pack (#ESD-003). The Research Pack contains all you need for NaV1.8 research: Antibodies recognizing different domains of the channel and NaV1.8 blockers, all in one economical package!
Compounds
Scientific Background
Related Products
Product Name
Cat #
Size
Anti-NaV1.8
ASC-016
1 x 0.2 ml
Anti-NaV1.8 (extracellular)
ASC-028
1 x 0.2 ml
Anti-NaV1.8-ATTO-594
ASC-016-AR
1 x 50 µl
Guinea pig Anti-NaV1.8
AGP-029
1 x 0.2 ml
A-803467
A-105
1 x 50 mg
Tolperisone hydrochloride
T-115
1 x 100 mg
VSTX3
STT-350
1 x 0.1 mg
Note A guinea pig polyclonal antibody (#AGP-029) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. 2-3 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 Expression of the α subunit isoform is developmentally and tissue specific.
Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission.
Recently, involvement of NaV1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6
NaV1.8 Channel Deluxe Research PackReferences
Lai, J. et al. (2003) Curr. Opin. Neurobiol.13, 291.
Renganathan, M. et al. (2003) Brain Res. 959, 235.
Fang, X. et al. (2002) J. Neurosci. 22, 7425.
Wu, L. et al. (2002) Neuro. Report13, 2547.
Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci.22, 27.