- $1427
- Alomone
- 以色列
- AK-465
- 2025年07月16日
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- 见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-465
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
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- 靶点：
见官方网站
- 抗体英文名：
pH-Sensitive K2P Channel Antibody Explorer Kit
- 抗体名：
pH-Sensitive K2P Channel Antibody Explorer Kit
- 规格：
18 Vials
pH-Sensitive K2P Channel Antibody Explorer Kit
A Screening Package of pH-Sensitive K2P Channel Antibodies Economically PricedCat #: AK-465
18 Vials
Alomone Labs is pleased to offer the pH-Sensitive K2P Channel Antibody Explorer Kit (#AK-465). The Explorer Kit contains pH-sensitive K2P channel antibodies, ideal for screening purposes.
- Compounds
- Scientific Background
Two-pore domain potassium (K2P) channels have four transmembrane domains, two pore-forming loops between transmembrane domains 1 and 2 as well as 3 and 4, and a large extracellular linker region between transmembrane domain 1 and the first pore-forming loop, which forms the K+ selectivity filter.
The TASK subfamily of this group is highly sensitive to variations in extracellular pH. TASK-1, TASK-2 and TASK-3 homo- and heteromers are inhibited by extracellular acidification but are left unaffected by intracellular pH changes. Acid-induced inhibition of TASK channel activity enhances nerve excitability and thus indirectly indicates the presence of acid. The high proton sensitivity of the TASK channels suggests a role in surveillance of tissue acidification by ischemia, inflammation or back-diffusion of luminal acid.
TREK-1 and TREK-2 do not respond to changes in extracellular pH but are inhibited by intracellular alkalization and are activated by intracellular acidification such that they become constitutively active.
TRESK K2P member is blocked by extra- and intracellular acidification and is activated by extra and intracellular alkalization.
Additional pH-sensitive K2P channels include TWIK-1 and TWIK-2 which are inhibited by intracellular acidification, TRAAK channels that are activated by intracellular alkalization but not acidification and lastly, TALK-1 and TALK-2 are blocked by extracellular acidification but are gated open by extracellular alkalization1.
References
- Holzer, P. (2009) Handb. Exp. Pharmacol. 194, 283.
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文献和实验Characterization of Calcium Channel Binding
. Dubel, S.J., Starr, T.V.B., Hell, J., Ahlijanian, M.K., Enyeart, J.J., Catterall, W.A., and Snutch, T.P. 1992. Molecular cloning of the α1 subunit of an ω‐conotoxin‐sensitive calcium channel. Proc. Natl. Acad
Single Primer ("Semi-Random") P
cresol red 2. T/TS 10.5 µL EDB 1 µL Taq Polymerase (Promega) @ 5 u/µL 1 µL TaqStart antibody (CloneTech) as delivered 3. EDB 2.5 mg/ml bovine serum albumin in 10 mM Tris, pH 8.3 References 1. S.R.J.A.M. Hermann
Characterization of Potassium Channel Binding
assay ( appendix 3A ) and calculation of IC 50 and K i (unit 1.3 ) Basic Protocol 3: Displacement Analysis of [3H]P 1075 Binding to Cultured A10 Cells
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