- $1110
- Alomone
- 以色列
- AK-205
- 2025年07月12日
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- 见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-205
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 靶点：
见官方网站
- 抗体英文名：
HCN Antibody Explorer Kit
- 抗体名：
HCN Antibody Explorer Kit
- 规格：
14 Vials
HCN Antibody Explorer Kit
A Screening Package of HCN Antibodies Economically PricedCat #: AK-205
14 Vials
Alomone Labs is pleased to offer the HCN Antibody Explorer Kit (#AK-205). The Explorer Kit contains HCN antibodies with their respective peptide control antigen. An ideal tool for screening purposes.
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-HCN1 |
APC-056 | 1 x 50 µl |
Guinea pig Anti-HCN1 |
AGP-203 | 1 x 50 µl |
Anti-HCN2 |
APC-030 | 1 x 50 µl |
Anti-HCN3 |
APC-057 | 1 x 50 µl |
Anti-HCN3 (extracellular) |
APC-083 | 1 x 50 µl |
Anti-HCN4 |
APC-052 | 1 x 50 µl |
Guinea pig Anti-HCN4 |
AGP-004 | 1 x 50 µl |
Note Guinea pig polyclonal antibodies (#AGP-203 & #AGP-004) are included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and have a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity1,2.
The Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated channel family (HCN), which is comprised of four homologous members, HCN1-4.
Each HCN subunit consists of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain for cyclic nucleotides (CNBD) in the cytoplasmic C-terminus2. The HCN subunits can form functional homomers and can also co-assemble into functionally heteromers2.
The channels are closely related to each other and share a homology of about 60%. However, their similarity decreases in the cytoplasmic N- and C-termini. The channels HCN1-4 mainly differ from each other in their speed of activation and the extent to which they are modulated by cAMP. HCN1, weakly affected by cAMP, is the fastest channel, followed by HCN2, HCN3 and HCN4.
HCN Antibody Explorer KitReferences
- Hughes, D.I. et al. (2012) J. Physiol. 590.16, 3927.
- Klueva, J. et al. (2012) Neurosignals 20, 35.
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文献和实验Dynabeads® Co-Immunoprecipitation Kit
实验原理 Antibodies (Ab) of your choice are covalently coupled to Dynabeads. Once antibodies have been coupled to the Dynabeads, the bead-bound antibody may then be used for co-immunoprecipitation experiments. Captured proteins
that need to be optimized, including the choice of antibody, the conditions for shearing chromatin using sonication and the analysis of immunoprecipitated DNA. The ChIP-IT Kit from Active Motif provides a complete solution to all potential problems associated with the ChIP
All-in-One Kit for Immunohistochemical Staining for Tissues with Antibodies
O2 in methanol for 10 minutes. Wash slides 3 times with 1X PBS for 2 minutes, each time and then proceed to primary antibody incubation. 3. Epitope Retrieval Protocol A sample epitope retrieval protocol developed for some Zymed® Antibodies
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