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- 20380-11-4
- 2025年07月16日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 yearsIn solvent: -80°C, 6 months; -20°C, 1 month
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
20380-11-4
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥600.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2100.0 |
27-Hydroxycholesterol
产品活性：27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.
研究领域：Others | Metabolic Enzyme/Protease
作用靶点：Estrogen Receptor/ERR | LXR | Endogenous Metabolite
In Vitro: 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer[1]. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors[2]. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities[3]. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload[4].
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文献和实验The term ribonuclease (RNase) is an imprecise term and is used to cover both enzymes that cause exonucleolytic cleavage and endonucleolytic cleavage of RNA. Exonucleases may cleave the RNA in 3′-5′ direction or vice versa
Procedure Dilute p27 monoclonal antibody 1:1000 (v/v) in Carbonate Coating Buffer. Add 100 µl/well and incubate o/n @ 4°C or 1 hr @37°C. Wash 3X with TBST (pour onto plate, empty into sink, hit onto towel 3x to clear wells
CD27 分子 CD27 常用单克隆抗体或代号： VIT14,S152,OKT18A 主要表达细胞： T, Bsub [T] 分子质量(kDa)和结构： p55(TNFR- SF)(同源二聚体) 功 能： CD70的配体,T细胞活化增殖 CD27 Marker of T cell activation CD27/CD70 interactions also regulate
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