Anti-Surfactant protein D (hum

Anti-Surfactant protein D (human)

Bioporto是一家体外诊断公司，专业为临床和科研提供一系列诊断试剂盒和抗体。其领先的产品组合包括了用于急性肾功能损伤诊断用的NGAL以及其它疾病检测用抗体。
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Cat. No.

HYB 246-04

Product name

Anti-Surfactant protein D (human)

Description

Mouse monoclonal antibody

Specificity

HYB 246-04 is specific for surfactant protein D (SP-D) from amniotic fluid, serum and bronchioalveolar lavage. HYB 246-04 does not influence SP-D’s binding to carbohydrates, but block binding to GP-340.

Immunogen

Native human SP-D purified from late pregnancy amniotic fluid 

Application

ELISA, WB

Species reactivity (positive)

Human

Species reactivity (negative)

Not determined

Subclass

IgG2a/k

Gene ID

6441

Clone number

10B2

Epitope

Epitope is localised within the C-terminal neck CRD (carbohydrate recognition domain) of SP-D

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Target

Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is approximately 700 ng/ml in healthy individuals (1).

Application 1

ELISA
HYB 246-04 can be used in ELISA (1, 2, 3).

Application 2

WB
HYB 246-04 can be used in Western blotting (1).