- $595
- BioPorto
- 丹麦
- CAM 035-01
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20ºC
- 保质期：
1年
- 库存：
30
- 供应商：
上海泽叶生物科技有限公司
- 抗体英文名：
Anti-yENaC (y−subunit epithelial sodium channel, neoepitope)
- 规格：
200ug
Anti-yENaC (y−subunit epithelial sodium channel, neoepitope)
Bioporto是一家体外诊断公司，专业为临床和科研提供一系列诊断试剂盒和抗体。其领先的产品组合包括了用于急性肾功能损伤诊断用的NGAL以及其它疾病检测用抗体。官方网站：www.bioporto.com
- Cat. No.
- CAM 035-01
- Product name
- Anti-yENaC (y−subunit epithelial sodium channel, neoepitope)
- Description
-
Mouse monoclonal antibody
- Specificity
-
CAM 035-01 is specific for the neoepitope generated after proteolytic cleavage of human yENaC and recognizes the C-terminal fragment.
- Immunogen
-
Synthetic peptide seguence: VGGSIIHKAC
- Application
- ELISA, WB, IHC-P, IHC-F, IF
- Species reactivity (positive)
- Human
- Species reactivity (negative)
- Not determined
- Clone number
- 11-35-1
- Epitope
-
CAM 035-01 is specific for the neoepitope generated after proteolytic cleavage of human ENaC and recognizes the C-terminal fragment starting from amino acid residue 182.
- Content
-
Available in 200 μL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
- Purification
- Protein-A purified
- Form
- Liquid
- Solvent
- 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
- Storage
- 4-8ºC without exposure to light. No precautions necessary during handling.
- Target
-
The epithelial sodium channel (ENaC) of the kidney is necessary for extracellular volume homeostasis and normal arterial BP. Activity of ENaC is enhanced by proteolytic cleavage of the y-subunit. In the y-subunit, putative cleavage sites for prostasin, kallikrein (similar site as prostasin), elastase, and plasmin exist. Prostasin is a glycosylphosphatidylinositol anchored apical serine protease expressed in the collecting duct that activates yENaC at a site close to but in the C-terminal direction to the furin cleavage with putative release of a 43-residue inhibitory tract.
- Application 1
-
ELISA
CAM 035-01 can be used in ELISA. - Application 2
-
WB
CAM 035-01 can be used in Western blot. - Application 3
-
IHC
CAM 035-01 can be used in IHC.
Immunohistochemical staining of a formalin-fixed, paraffin-embedded kidney tissue with CAM 035-01. Courtesy of Per Svenningsen, PhD. - Application 4
-
IF
CAM 035-01 can be used in immunofluorescence.
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文献和实验CFTR Regulation of Epithelial Sodium Channel
-activated Cl− channel. Intense research following the cloning of the CFTR gene has extended the role of the CFTR beyond that of a Cl− channel. One of the best recognized, yet still controversial, functions of the CFTR is its ability to modulate
Epithelial Sodium Channel in Planar Lipid Bilayers
Amiloride-sensitive Na+ channels belong to the epithelial Na+ channel (ENaC)-degenerin superfamily of ion channels. In addition to their key role in sodium handling, they serve diverse functions in many tissues. Improper functioning of ENaC
The amiloride-sensitive epithelial Na+ channel (ENaC) is typically composed of three structurally related subunits termed α, β, and γ. We describe methods to determine the functional subunit stoichiometry of ENaC based on a biophysical
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