重组人T细胞免疫球蛋白黏蛋白3(TIM-3)(HAVCR2)

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括重组人T细胞免疫球蛋白黏蛋白3(TIM-3)(HAVCR2)销*(代"售")在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：重组人T细胞免疫球蛋白黏蛋白3(TIM-3)(HAVCR2)销*(代"售")
品牌：百奥莱博
编号：JN1157
英文名：Recombinant Human T cell Immunoglobulin and Mucin Domain-3
产地：国产|进口
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Ser22-Arg200在C端含有Fc标签和His标签

TIM-3质量控制：＞95%(还原性SDS-PAGE)

TIM-3制剂：冻干品

TIM-3保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TIM-3复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TIM-3：
Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

关于重组人T细胞免疫球蛋白黏蛋白3(TIM-3)(HAVCR2)销*(代"售")的更详细说明，请致电我公司咨询，我们将以最饱满的热情为您提供解答，此外，我公司专业供应下列产品：

·重组人Lacritin蛋白(LACRT)
编号：JN1941
英文名称：Recombinant Human Lacritin
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Ala19-Ala138在N端含有His标签。

Lacritin/LACRT质量控制：＞95%(还原性SDS-PAGE)

Lacritin/LACRT制剂：冻干品

Lacritin/LACRT保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Lacritin/LACRT复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Lacritin/LACRT：
Extracellular glycoprotein lacritin (Lacritin) is a secreted protein which consists of 119 amino acids after cleavage of the N-terminal signal peptide and displays several predicted alpha helices, mostly in the C-terminal half. Lacritin is highly expressed in the lacrimal gland, localizes primarily to secretory granules and secretory fluid. Lacritin modulates lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. Lacritin is thus a multifunctional prosecretory mitogen with cell survival activity. Natural or bacterial cleavage of lacritin releases a C-terminal fragment that is bactericidal. Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated off-on switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1s core protein.


重组人T细胞免疫球蛋白黏蛋白3(TIM-3)(HAVCR2)销*(代"售")关键词：重组人T细胞免疫球蛋白黏蛋白3蛋白,重组人HAVCR2,重组人TIM-3,JN1157


·重组人Dutpase
编号：JN1756
英文名称：Recombinant Human Deoxyuridine 5-Triphosphate Nucleotidohydrolase,Mitochondrial
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Asn164表达纯化得来。

Dutpase质量控制：＞95%(还原性SDS-PAGE)

Dutpase制剂：液体

Dutpase保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于Dutpase：
Deoxyuridine 5-Triphosphate Nucleotidohydrolase Mitochondrial (dUTPase) belongs to the dUTPase family. dUTPase exits as a homotrimer and is involved in nucleotide metabolism. dUTPase produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. The dUTPase increase in PCR product yield, length and fidelity enables further down-stream applications. These effects make dUTPase useful in PCR fidelity and yield-sensitive applications. dUTPase is specific for dUTP and is critical for the fidelity of DNA replication and repair.


重组人T细胞免疫球蛋白黏蛋白3(TIM-3)(HAVCR2)销*(代"售")关键词：重组人T细胞免疫球蛋白黏蛋白3蛋白,重组人HAVCR2,重组人TIM-3,JN1157


·重组人线粒体凋亡诱导因子1(AIFM1)
编号：JN0674
英文名称：Recombinant Human Apoptosis-Inducing Factor 1, Mitochondrial
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Glu121-Asp613在N端含有His标签。

AIFM1质量控制：＞95%(还原性SDS-PAGE)

AIFM1制剂：冻干品

AIFM1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

AIFM1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于AIFM1：
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.

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