重组人HAVCR2蛋白|TIM3

产品编号：KMP2301

产品名称：Human HAVCR2 Protein, Fc Tag, Avi Tag

中文名称： 重组人HAVCR2蛋白

中文全称：重组人甲型肝炎病毒细胞受体2蛋白

产品描述：产品描述：The Human HAVCR2 Protein(KMP2301) is produced in HEK293 Cells and the target gene encoding Ser22-Arg200 is expressed with a Fc, Avi tag at the C-terminus.

产品别称：甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

分子名称：HAVCR2

预测分子量：19.87 kDa

物种：Human

宿主：HEK293 Cells

规格：50ug, 100ug, 200ug

纯化方式：Affinity purification

纯度：>85% as determined by SDS-PAGE

内毒素水平：<1.0 EU/ug determined by the LAL method

缓冲体系：PBS, pH7.4

Uniport:A0A8Q3SJ74

产品背景：Hepatitis A virus cellular receptor 2(HAVCR2) is a single-pass type I membrane protein and it contains 1 Ig-like V-type(immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte(Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4(MIM 186940)-positive T helper lymphocytes can be divided into types 1(Th1) and 2(Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

说明：This product is for research use only.