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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
(-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
130405-40-2
- 规格：
1 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥834.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1550.0 |
| 规格： | 10 mg | 产品价格： | ￥2450.0 |
| 规格： | 25 mg | 产品价格： | ￥4350.0 |
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(-)-Catechin gallate
CAS No. : 130405-40-2
MCE 国际站：(-)-Catechin gallate
产品活性：(-)-Catechin gallate 是绿茶儿茶素中的一种微量组分。(-)-Catechin gallate 抑制 COX-1 和 COX-2 活性。
作用靶点：COX
In Vitro: (-)-Catechin gallate (CG) directly interacts with DNA oligomers and inhibits the activity of COX-1 and COX-2 enzymes, the gene expression of matrix metalloproteinase-9 in macrophage-differentiated HL-60 myeloid leukemia cells, the adipocyte uptake of glucose by the transporter, GLUT4, and the activities of various proteasomes, i.e., the multicatalytic proteases responsible for the degradation of most cellular proteins. The relative cytotoxicities of a 3-day exposure to (-)-Catechin gallate are determined for cancerous CAL27 and HSG cells, immortalized epithelioid S-G cells, and normal HGF-1 gingival fibroblasts. The concentration at which toxicity (P≤0.01) initially occur is 25 μM (-)-Catechin gallate for S-G cells, 50 μM (-)-Catechin gallate for CAL27 cells, 62.5 μM (-)-Catechin gallate for HSG cells and 75 μM (-)-Catechin gallate for HGF-1 fibroblasts. The calculated neutral red (NR50) values for a 3-day exposure to (-)-Catechin gallate are 58 μM for S-G cells, 62 μM for CAL27 cells, 90 μM for HSG cells and 132 μM for HGF-1 fibroblasts.
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, apples, and berries. Such flavanones as naringin are typically present in citrus fruit, and flavanols, particularly catechin, are present as catechin gallate in such beverages as green or black tea and wine. Some major sources of flavonoids are outlined
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