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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
14-dehydro Andrographolide; AP10
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
42895-58-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1390.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1900.0 |
| 规格： | 10 mg | 产品价格： | ￥2800.0 |
| 规格： | 25 mg | 产品价格： | ￥4850.0 |
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14-Deoxy-11,12-didehydroandrographolide
CAS No. : 42895-58-9
MCE 国际站：14-Deoxy-11,12-didehydroandrographolide
产品活性：14-Deoxy-11,12-didehydroandrographolide 是 Andrographolide 的类似物。14-Deoxy-11,12-didehydroandrographolide 抑制 NF-κB 活化。
研究领域：NF-κB
作用靶点：NF-κB
In Vitro: 14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.
In Vivo: 14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.
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