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- 文献和实验
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- 保存条件：
4°C, protect from light
- 英文名：
Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1257-08-5
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥275.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥250.0 |
| 规格： | 10 mg | 产品价格： | ￥350.0 |
| 规格： | 25 mg | 产品价格： | ￥580.0 |
| 规格： | 50 mg | 产品价格： | ￥800.0 |
| 规格： | 100 mg | 产品价格： | ￥1100.0 |
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(-)-Epicatechin gallate
CAS No. : 1257-08-5
MCE 国际站：(-)-Epicatechin gallate
产品活性：(-)-Epicatechin gallate (Epicatechin gallate) 抑制环加氧酶-1 (COX-1) , IC50 为 7.5 μM。
研究领域：Immunology/Inflammation | Autophagy | Anti-infection
作用靶点：COX | Autophagy | Virus Protease
In Vitro: (-)-Epicatechin gallate (Epicatechin gallate) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.
In Vivo: (-)-Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of (-)-Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg.
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文献和实验2017 年 8 月 31 日，山东烟台毓璜顶医院呼吸内科邹慎春为第一作者和通讯作者 Yao Zhang 在《分子医学报告》（Molecular Medicine Reports）发表题为《Epicatechin induces apoptotic and autophagic cell death in NCI-H2172 non‑ small cell lung cancer cells along with concomitant mitochondrial membrane
. 1) ; and (2) condensed tannins, or proanthocyanidins, consisting of oligomers of two or more flavan-3-ols, such as catechin, epicatechin, or the corresponding gallocatechin (Fig. 2) . Tannins have a very high affinity for proteins and form protein-tannin complexes
are observed for epicatechin gallate, epigallocatechin gallate, quercetin, fisetin, epigallocatechin, catechin, and caffeic acid in this order, in accord with the number and position of the –OH groups as well the conjugation level of the molecule
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