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- MedChemExpress(MCE)
- 美国
- HY-B0763
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
KC-404; AV-411; MN-166
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥281.0 |
| 规格： | 10 mg | 产品价格： | ￥450.0 |
| 规格： | 50 mg | 产品价格： | ￥650.0 |
| 规格： | 100 mg | 产品价格： | ￥880.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Ibudilast
CAS No. : 50847-11-5
MCE 国际站：Ibudilast
产品活性：Ibudilast (KC-404; AV-411; MN-166) 是一种环腺苷酸磷酸二酯酶 (PDE) 抑制剂。Ibudilast 具有抗血小板聚集作用。Ibudilast 抑制气管平滑肌收缩性，可用于哮喘的研究。Ibudilast 可能是一种有效的神经保护和抗痴呆活性分子，可对抗活化小胶质细胞的神经毒性。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phosphodiesterase (PDE)
In Vitro: Ibudilast (1~100 μM; 24 hours; microglia) suppresses both IL-1β and IL-6 production at 100 μM, and significantly suppresses TNF-α production at 10 and 100 μM.
?Ibudilast (1~100 μM; 48 hours; neuronal cells) significantly increases the neuronal survival rate. Ibudilast (1~100 μM; 48 hours; microglia) inhibits the production of superoxide and NO.
?Ibudilast upregulates the production of IL-10 in a dose-dependent manner. Ibudilast increases NGF mRNA and protein levels and GDNF and NT-4 mRNA expression. Ibudilast decreases the apoptotic changes observed in the neuronal cells in a dose-dependent manner.
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