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- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
Hydroxycarbamide
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
127-07-1
- 规格:
10 mM * 1 mL/500 mg/1 g/5 g
| 规格: | 10 mM * 1 mL | 产品价格: | ¥500.0 |
|---|---|---|---|
| 规格: | 500 mg | 产品价格: | ¥400.0 |
| 规格: | 1 g | 产品价格: | ¥500.0 |
| 规格: | 5 g | 产品价格: | ¥650.0 |
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Hydroxyurea
CAS No. : 127-07-1
MCE 国际站:Hydroxyurea
产品活性:Hydroxyurea 通过抑制核糖核苷酸还原酶抑制 DNA 合成的细胞凋亡诱导剂。Hydroxyurea 具有抗正痘病毒活性。
研究领域:Cell Cycle/DNA Damage | Autophagy | Apoptosis | Anti-infection
作用靶点:DNA/RNA Synthesis | Autophagy | Apoptosis | HIV | Orthopoxvirus
In Vitro: Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages.
In Vivo: Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice.
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