[结肠癌，160点]HColA160CS01 添加MLH1和

Study Designs in Genetic Epidemiology

Identification of germline mutations that may modulate individual risk of developing cancer is a rapidly developing field. Over the last few decades, germline mutations in p53, BRCA1, BRCA2, APC, MLH1, MSH2, and MSH6 have been identified

Analysis and Interpretation of RNA Splicing Alterations in Genes Involved in Genetic Disorders

Germ line mutations in genes involved in hereditary cancer syndromes, such as BRCA1 and BRCA2 in breast cancer and MSH2 , MSH6 , MLH1 , and PSM2 in hereditary nonpolyposis colorectal cancer (HNPCC, more recently indicated as Lynch syndrome

MicroRNA与DNA修复基因的关闭相关联

，MicroRNA的失调可能导致基因组不稳定，这是癌症细胞的一个特点，”主要研究员Carlo M. Croce医生，分子病毒学、免疫学和医学遗传学教授，同时是美国俄亥俄州立的人类癌症遗传学主任。 “我们发现，miR-155主要作用和下调错配修复基因，miR – 155高表达引起基因组改变的增加，这促进癌症的发生，”他说。 这项研究发表在最新一期的美国国家科学院院刊（PNAS），显示如下： 在一个大肠癌细胞株中，过表达miR－155表达分别降低了人类错配修复基因MLH1、MSH2和MSH6表达的672