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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Exportin-2.
- 亚型:
Rabbit Ig
- 形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件:
Store at -20°C.
- 克隆性:
多克隆
- 标记物:
见下方详细说明
- 适应物种:
H, M, R
- 保质期:
1-2年
- 抗原来源:
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Exportin-2.
- 目录编号:
251449
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Rabbit
- 应用范围:
E, WB, IHC
- 浓度:
见详细说明信息
- 靶点:
Exportin-2
- 抗体英文名:
Exportin-2 Antibody
- 抗体名:
Exportin-2 Antibody
- 规格:
0.1 mg
Exportin-2 Antibody产品详细介绍:
| 产品名称: | Exportin-2 Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 251449 |
| 规格: | 0.1 mg |
| 产品描述: | Exportin-2 (CAS; Cellular apoptosis susceptibility protein; Exportin-2; Exp2; Importin-alpha re-exporter; Chromosome segregation 1-like protein; CSE1L; CAS; XPO2) mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus, Exprotin-2 binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) causes release of importin-alpha from the export receptor. Exportin-2 then returns to the nuclear compartment and mediates another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| 克隆类型: | Rabbit Polyclonal Antibody |
| 亚型: | Rabbit Ig |
| 免疫原: | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Exportin-2. |
| 适用物种: | H, M, R |
| 应用范围: | E, WB, IHC |
| 应用说明: | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别名: | CAS; Cellular apoptosis susceptibility protein; Exportin-2; Exp2; Importin-alpha re-exporter; Chromosome segregation 1-like protein; CSE1L; CAS; XPO2 |
| 形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献: |
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文献和实验存在于细胞核中识别并与输出信号结合的蛋白质, 帮助核内物质通过核孔复合物输出到细胞质, 而后快速通过核孔复合物回到细胞核。
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