DDR1 (Epithelial discoidin domain-containing receptor 1, CD167a) is a receptor tyrosine kinase involved in cell-cell interactions and recognition. It is expressed in epithelial cells especially in the kidney, lung, gastrointestinal tract, and brain, and more highly in human breast, ovarian, esophageal, and pediatric brain tumors. Types I-VI collagen all induce the autophosphorylation of DDR1. Collagen regulates the interaction of DDR1 with KIBRA (WWC1), activating MAPK; these events are involved in mammary gland development.
克隆类型:
Rabbit Polyclonal Antibody
亚型:
Rabbit Ig
免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human DDR1.