- ￥3000 - 3999
- Abbiotec
- 美国
- 250732
- 2025年07月14日
- E, WB, IHC
- Rabbit
- H, M, R, B, P, Rb
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD61.
- 亚型：
Rabbit Ig
- 形态：
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
多克隆抗体
- 标记物：
见下方详细说明
- 适应物种：
H, M, R, B, P, Rb
- 宿主：
Rabbit
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
CD61
- 抗体英文名：
CD61 Antibody
- 抗体名：
CD61 Antibody
- 规格：
0.1 mg
CD61 Antibody产品详细介绍：
| 产品名称： | CD61 Antibody |
| 说明书： | http://www.abbiotec.com/antibodies/cd61-antibody【参考图片】 |
| 货号： | 250732 |
| 规格： | 0.1 mg |
| 产品描述： | CD61, also called integrin beta-3, belongs to the integrin protein family that participates in cell adhesion and cell-surface mediated signalling by forming heterodimers of alpha and beta integrin chains. Integrin alpha-V/beta-3 is a receptor for cytoactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. These two integrins recognize the sequence RGD in a wide array of ligands. Integrin IIb/IIIa recognizes the sequence HHLGGGAKQAGDV in fibrinogen gamma chain. Following activation, integrin alpha-IIb/beta-3 supports platelet/platelet interaction through binding of soluble fibrinogen, leading to rapid platelet aggregation which physically plugs ruptured endothelial surface. Defects in CD61 are a cause of Glanzmann thrombasthenia, a blot clot disorder. |
| 克隆类型： | Rabbit Polyclonal Antibody |
| 亚型： | Rabbit Ig |
| 免疫原： | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CD61. |
| 适用物种： | H, M, R, B, P, Rb |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
| 别名： | Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD61; ITGB3; GP3A |
| 形态： | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验CD61 分子 CD61 常用单克隆抗体或代号： Y2/51,CLB- thromb/1;(VNR- b 链,integrin b 3) 主要表达细胞： Pt,Meg [Pt] 分子质量(kDa)和结构： gp105,血小板GPⅢa,与CD51组成VNR,与CD41组成a Ⅱbb 3 功 能： 血小板凝集和活化 CD61 Aka platelet glycoprotein IIb
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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