Pifithrin-α-HBr

概述

• 产品名称
  Pifithrin-α-HBr
• 描述
  p53 Inhibitor
• 生物学描述
  p53 Inhibitor. Specifically blocks tumor supressor p53 transcriptional activity and can supress heat shock and glucocorticoid signalling pathways. Additionally offers protection to cells from p53 mediated apoptosis. Active in vivo; protects mice from chemotherapy side effects associated with p53 induction. Also aryl hydrocarbon receptor (AHR) agonist.
• 纯度
  > 98%
• 常规说明

  Pifithrin-?-HBr is light senstive and it is recommended that the compound is protected from light.

性能

• 化学名称
  1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
• 分子量
  367.30
• 化学结构
  
• 分子式
  C₁₆H₁₈N₂OS.HBr
• CAS编号
  63208-82-2
• PubChem识别号
  9929138
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in DMSO to 100 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  Br.Cc1ccc(cc1)C(=O)CN2C=3CCCCC=3SC2=N
• 来源

  Synthetic