Paclitaxel

概述

• 产品名称
  Paclitaxel
• 描述
  Anticancer agent
• 别名
  • Taxol
• 生物学描述

  Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.

• 纯度
  > 98%

性能

• 化学名称
  5β,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 分子量
  853.91
• 化学结构
  
• 分子式
  C₄₇H₅₁NO₁₄
• CAS编号
  33069-62-4
• PubChem识别号
  36314
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in DMSO to 100 mM and in ethanol to 25 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

   

  Note: Some researchers have found solubility issues in PBS. The recommended procedure (from researcher feedback) for successful solubilisation is as follows: Solubilise 10 mg of ab120143 in 1.25 mL ethanol absolute, mix well, add 1.25mL Cremophor, homogenise. Store at -20°C and after 24 h, defreeze quickly and solubilise in PBS, no crystallisation observed. Please note, Abcam has not yet tested this method.

   

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  O=C(N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]5C[C@@]6(O)[C@@H](OC(=O)c2ccccc2)[C@H]3[C@@](C)([C@@H](O)C[C@H]4OC[C@@]34OC(C)=O)C(=O)[C@H](OC(C)=O)C(=C5C)C6(C)C)c7ccccc7
• 来源

  Synthetic