Paclitaxel

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本试剂(Paclitaxel)
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简介：
货 号：P-9600
名 称：Paclitaxel
别 名：Paclitaxel
C A S ：33069-62-4
分子量：853.91
分子式：C47H51NO14
纯 度：HPLC/TLC:>99%
说 明：Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 200 mg/mL; soluble in ethanol at 40 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
文 献：Antitumor and antileukemic agent isolated from the bark of the yew tree, Taxus brevifolia. Wani, M.C., et al. "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia." J. Am. Chem. Soc. 93: 2325-2327 (1971). McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms" Ann. Int. Med. 111: 273-279 (1989). Binds to β-tubulin and promotes the assembly of microtubules that resist depolymerization preventing normal cell division. Rowinsky, E.K., et al. "Taxol: a novel investigational antimicrotubule agent." J. Natl. Cancer Inst. 82: 1247-1259 (1990). Parekh, H. and Simpkins, H. "The transport and binding of taxol." Gen. Pharmacol. 29: 167-172 (1997). Jordan, A., et al. "Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle investigational antimicrotubule agent." Med. Res. Rev. 18: 259-296 (1998). Induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway that results in Bcl-2 phosphorylation. Wang, T.H., et al. "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells." J. Biol. Chem. 274: 8208-8216 (1999). Shtil, A.A., et al. "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells." Oncogene 18: 377-384 (1999). Srivastava, R.K., et al. "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase." Mol. Cell. Biol. 18: 3509-3517 (1998). Torres, K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death are concentration dependent." Cancer Res. 58: 3620-3626 (1998).