EMD 386088 hydrochloride

概述

• 产品名称
  EMD 386088 hydrochloride
• 描述
  Potent 5-HT₆ agonist
• 生物学描述
  Potent 5-HT₆ agonist (IC₅₀ = 7.4 nM in ³H-LSD binding and EC₅₀ = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC₅₀ values are 110 (5-HT_1D), 180 (5-HT_1B), 240 (5-HT_2A), 450 (5-HT_2C), 620 (5-HT₄), 660 (5-HT_1A ) and 3000 nM (5-HT₇)). Shows moderate affinity at 5-HT₃ receptors (IC₅₀ = 34 nM). Impairs memory in vivo.
• 纯度
  > 98%

性能

• 化学名称
  5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-Indole hydrochloride
• 分子量
  283.20
• 化学结构
  
• 分子式
  C₁₄H₁₅N₂.HCl
• CAS编号
  54635-62-0
• PubChem识别号
  56972198
• 存放说明
  Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in water to 25 mM (with heating) and in DMSO to 100 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  Cl.Clc2ccc3nc(C)c(C1=CCNCC1)c3c2
• 来源

  Synthetic