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- 2025年10月02日
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- 英文名：
Human sTNF Receptor Type I
TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein.
Manufactured using all Animal-Free reagents.
Source:E.coli
Synonyms:soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, p60, p55, CD120a, TNFR1
AA Sequence:MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN
Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-α, is 0.05 µg/ml.
Country Of Origin: USA
Research Use Only: Not for use in diagnostic or therapeutic procedures.
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文献和实验（IFO 228） 酵母膏 1.0 g 牛肉膏 1.0 g NZ Amine,type A 2.0 g 葡萄糖 10.0 g 琼脂 20.0 g 蒸馏水 1000 ml pH 7.3 73. Harroldˊs M40Y （ATCC 319） 麦芽膏 20.0 g 酵母膏 5.0 g 蔗糖 400.0 g 琼脂 20.0 g 蒸馏水 1000 ml 74. PSA
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Characterization of 5‐HT1A,B and 5‐HT2A,C Serotonin Receptor Binding
transduction differences between 5‐hydroxytryptamine type 2A and type 2C receptor systems. Mol. Pharmacol 46:477‐484. Boess, F.G. and Martin, I.L. 1994. Molecular biology of 5‐HT
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