KN-62

概述

• 产品名称
  KN-62
• 描述
  CaM kinase II inhibitor. P2X₇ antagonist.
• 生物学描述
  Cell-permeable, reversible and selective inhibitor of CaM kinase II (IC₅₀ = 500 nM). Interacts with the calmodulin binding site of the enzyme. At higher concentrations reported to inhibit GSK3β, PRAK and MAPKAP-K2. Also potent non-competitive antagonist at the P2X₇ receptor (IC₅₀ = 15 nM).
• 纯度
  > 98%

性能

• 化学名称
  4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester
• 分子量
  721.84
• 化学结构
  
• 分子式
  C₃₈H₃₅N₅O₆S₂
• CAS编号
  127191-97-3
• PubChem识别号
  5312126
• 存放说明
  Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
• 溶解度概述
  Soluble in DMSO to 100 mM
• 处理

  Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

• SMILES
  O=C([C@H](Cc3ccc(OS(=O)(=O)c2cccc1cnccc12)cc3)N(C)S(=O)(=O)c5cccc4cnccc45)N6CCN(CC6)c7ccccc7
• 来源

  Synthetic