- ￥285
- Sigma/国产
- 上海研谨/杭州研谨
- YJ-B24479-100mg
- 2026年10月20日
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- 文献和实验
- 技术资料
- 保存条件：
2-8℃
- 保质期：
见产品包装
- 英文名：
Carbamazepine
- 库存：
现货
- 供应商：
上海研谨/杭州研谨
- CAS号：
298-46-4
- 规格：
100mg
卡马西平
分析标准品,HPLC≥98%
Carbamazepine
CAS号：298-46-4
分子式：C15H12N2O
分子量：236.27
MDL：MFCD00005073
别名：痛惊宁;立痛定;卡巴咪嗪;5H-二苯并[b,f]氮杂卓-5-甲酰胺
|
货号 |
规格/参数/品牌 |
价格 |
货期 |
|
YJ-B24479-100mg |
分析标准品,HPLC≥98% |
￥285.00 |
现货 |
|
JS45626-5g |
≥98% |
￥145.00 |
现货 |
|
JS45626-25g |
≥98% |
￥288.00 |
现货 |
|
JS45626-100g |
≥98% |
￥605.00 |
现货 |
|
JS45626-500g |
≥98% |
￥1930.00 |
2-3天 |
产品介绍
Carbamazepine是压敏钠离子通道阻断剂，IC50为 131 μM。
熔点：191-192℃
沸点：411℃ at 760mmHg
外观：白色或类白色结晶性粉末。
溶解性：DMSO : 100 mg/mL (423.24 mM; Need ultrasonic)
H2O : 0.1 mg/mL (0.42 mM; Need ultrasonic)
储存条件：2-8℃
注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。
参考文献(27篇)
27. [IF=12.5] Yongwei Gu et al."Engineering hybrid nanoparticles for targeted codelivery of triptolide and CYP3A4-siRNA against pulmonary metastatic melanoma."Science Advances.2025 Jul;11(30)
26. [IF=14.6] Niping Li et al."The toxic components, toxicological mechanism and effective antidote for Gelsemium elegans poisoning."Acta Pharmaceutica Sinica B.2025 Jul;:
25. [IF=4.8] Hui Zong et al."Integrated UPLC–MS/MS and UPLC–Q–TOF–MS/MS analysis to reveal pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine in rats."Frontiers in Pharmacology.2025 May;16:
24. [IF=2.6] Li Jingya et al."Exploring the mechanism of carbamazepine decreasing testosterone levels based on cAMP/PKA/CREB pathway."3 Biotech.2024 Dec;14(12):1-13
23. [IF=7.7] Jing-Jing Gao et al."Harnessing polysialic acid (PSA)-embedded exudate-absorbing hydrogel for on-demand trigeminal neuralgia treatment."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Nov;:138035
22. [IF=4.9] Qing Qian et al."UHPLC method for simultaneous assessment of pharmacokinetic parameters of co-administered voriconazole and omeprazole using rat plasma."MICROCHEMICAL JOURNAL.2024 Dec;207:111729
21. [IF=6.6] Dan Ye et al."Natural Coptidis Rhizoma Nanoparticles Improved the Oral Delivery of Docetaxel."International Journal of Nanomedicine.
20. [IF=12.2] Tingting Chai et al."Multidimensional occurrence and diet risk of emerging contaminants in freshwater with urban agglomerations."JOURNAL OF HAZARDOUS MATERIALS.2024 Aug;474:134813
19. [IF=3.4] Haiwei Cao et al."Simultaneous monitoring of seven antiepileptic drugs by dried blood spot and dried plasma spot sampling: method validation and clinical application of a LC–MS/MS-based technique."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS".2024 Ma
18. [IF=1.8] Fan Wu et al."Effect of berberine on pharmacokinetics and pharmacodynamics of atorvastatin in hyperlipidemia rats."XENOBIOTICA.
17. [IF=2.2] Dan-Dan Hong et al."Application of Ganoderma lucidum extract for constructing an oral docetaxel delivery system."JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY.
16. [IF=10.7] Chunfang Zhao et al."An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds."Journal of Advanced Research.2023 Nov;:
15. [IF=4.6] Weiwei Zhang et al."A Pharmacokinetic Study of Sixteen Major Bioactive Components of Jinshui-Huanxian Granules in Pulmonary Fibrosis Model and Control Rats Using Orbitrap Fusion Mass Spectrometry."MOLECULES.10.3390/molecules28186492
14. [IF=5.589] Dongli Qi et al."Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: fabrication, characterization, pharmacokinetics, and pharmacodynamics."EUROPEAN JOURNAL OF
13. [IF=2.838] Wang Shuo et al."Toxicity and toxicokinetics of the ethanol extract of Zuojin formula."BMC Complementary Medicine and Therapies.2022 Dec;22(1):1-14
12. [IF=16.744] Chenchen Meng et al."Laminar membranes assembled by ultrathin cobalt-copper oxide nanosheets for nanoconfined catalytic degradation of contaminants."CHEMICAL ENGINEERING JOURNAL.2022 Dec;449:137811
11. [IF=7.312] Yunyun Li et al."Mass transfer enhancement for rapid, selective extraction of pharmaceuticals by enlarging the microporous on isostructural zeolitic imidazolate Framework-8."SEPARATION AND PURIFICATION TECHNOLOGY. 2022 Jul;293:121102
10. [IF=0.837] Shi Xiangjun et al."Preparation and In Vitro/Vivo Evaluation of New Celecoxib Solid Dispersions with Co-Carrier Containing Aerosil and Poloxamer 188."Pharm Chem J+. 2021 Jan;54(10):1033-1039
9. [IF=1.902] Tingting Liu et al."Pharmacokinetic–pharmacodynamic modeling analysis and anti-inflammatory effect of Wangbi capsule in the treatment of adjuvant-induced arthritis."Biomed Chromatogr. 2021 Jul;35(7):e5101
8. [IF=5.81] Zhao Jing et al."Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice."Front Pharmacol. 2021 Jun;0:1426
7. [IF=6.4] Jing Zhao et al."Natural Nano-Drug Delivery System in Coptidis Rhizoma Extract with Modified Berberine Hydrochloride Pharmacokinetics."Int J Nanomed. 2021; 16: 6297–6311
6. [IF=6.639] Fanchao Meng et al."Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel."Cancers. 2019 Oct;11(10):1571
5. [IF=1.902] Yining Zhao et al."Simultaneous quantitation of 23 bioactive compounds in Tanreqing capsule by high-performance liquid chromatography electrospray ionization tandem mass spectrometry."Biomed Chromatogr. 2019 Jul;33(7):e4531
4. 李荣荣,赵迪,李蒙蒙,舒胜男,王佩阳,李焕茹,冯素香.基于UHPLC-Q Exactive-Orbitrap高分辨质谱研究浙贝母和陈皮主要成分在大鼠体内的代谢物[J].药物分析杂志,2020,40(08):1413-1424.
3. 刘冲冲,孙江燕,董笑克,王凯悦,李中浩,吴婧,黎莉莉,刘金民.柴贝止痫汤及其吸收成分贝母素甲对大鼠脑内卡马西平含量的影响及其机制[J].中国实验方剂学杂志,2019,25(19):32-38.
2. 孙江燕,刘冲冲,袁斯远,王潇慧,刘金民.柴贝止痫汤及其主要入血成分柴胡皂苷a对癫痫模型大鼠卡马西平脑内分布的影响[J].中医杂志,2019,60(08):689-695.
1. 李荣荣、赵迪、李蒙蒙、舒胜男、王佩阳、李焕茹、冯素香. 基于UHPLC-Q Exactive-Orbitrap高分辨质谱研究浙贝母和陈皮主要成分在大鼠体内的代谢物[J]. 药物分析杂志, 2020, v.40(08):86-97.
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文献和实验佚名 卡马西平（carbamazepine）又称酰胺咪嗪。 【药理作用和临床应用】卡马西平的作用机制与苯妥英钠相似。治疗浓度时能阻滞Na+通道，抑制癫痫灶及其周围神经元放电。对复杂部分发作（如精神运动性发作）有良好疗效，至少2/3病例的发作可得到控制和改善。对大发作和部分性发作也为首选药之一。对癫痫并发的精神症状，以及锂
佚名 丙戊酸钠（sodium valproate）对各种类型的癫痫发作都有一定疗效。对失神小发作的疗效优于乙琥胺，但因丙戊酸钠有肝毒性，临床仍愿选用乙琥胺。对全身性肌强直-阵挛性发作有效，但不及苯妥英钠和卡马西平。对非典型小发作的疗效不及氯硝西泮。对复杂部分性发作的疗效近似卡马西平。对其他药物未能控制的顽固性癫痫有时可能奏效。
。还见粒细胞缺乏、血小板减少、再生障碍性贫血。偶见肝脏损害。应定期作血常规和肝功能检查。 妊娠早期用药，偶致畸胎，如腭裂等。静脉注射过快时，可致心律失常、心脏抑制和血压下降，宜在心电图监护下进行。 【药物相互作用】苯妥英钠为肝药酶诱导剂，能加速多种药物，如皮质类固醇和避孕药等的代谢而降低药效。卡马西平能降低苯妥英钠的血浓度，苯妥英钠也能降低卡马西平的血浓度。苯巴比妥能通过药酶诱导作用，加速苯妥英钠的代谢，又可通过竞争性抑制减弱其灭活，因此影响不确定。但苯妥英钠能提高苯巴比妥的血浓
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