Ac-Gly-BoroPro,886992-99-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Ac-Gly-BoroPro

CAS No. : 886992-99-0

MCE 国际站：Ac-Gly-BoroPro

产品活性：Ac-Gly-BoroPro是选择性的 FAP 抑制剂，K_i 值为23 nM。

研究领域：Immunology/Inflammation

作用靶点：FAP

In Vitro: FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K_i=23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K_i=377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K_i values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.

相关产品：Bioactive Compound Library Plus  |  FAPI-46  |  FAPI-4  |  FAP-2286  |  Sibrotuzumab  |  OncoFAP  |  Suc-Gly-Pro-AMC  |  NH2-UAMC1110 TFA  |  FAP-IN-2 TFA  |  FAPI-34  |  NOTA-FAPI  |  FAPI-2  |  3BP-3940  |  ARI-3099  |  FAP-IN-1  |  FAPI-2 TFA  |  FAPI-74  |  Fluorogen binding modulator-1  |  FSDD0I  |  FSDD1I  |  FSDD3I  |  Zilganersen  |  Zilganersen sodium

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds