CCR2 antagonist 4,226226-39-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CCR2 antagonist 4

CAS No. : 226226-39-7

MCE 国际站：CCR2 antagonist 4

产品活性：CCR2 antagonist 4 (Teijin compound 1) 是一种高效、特异的 CCR2 拮抗剂，对 CCR2b 的 IC₅₀ 值为 180 nM。CCR2 antagonist 4 对 MCP-1 诱导的趋化作用有较强的抑制作用，其 IC₅₀ 为 24 nM。

研究领域：GPCR/G Protein  |  Immunology/Inflammation

作用靶点：CCR

In Vitro: Ile263 and Thr292 in CCR2 contribute significantly to binding of Teijin compound 1 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4.
In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.

相关产品：Pirfenidone  |  Maraviroc  |  RS 504393  |  Bindarit  |  INCB3344  |  BX471  |  PF-4136309  |  RS102895 hydrochloride  |  Cenicriviroc  |  TAK-779  |  CCR6 inhibitor 1  |  Zelnecirnon  |  CCR6 antagonist 1  |  AZ084  |  ZK756326 dihydrochloride  |  AZD2098  |  GW 766994  |  R243  |  7,4'-Dihydroxyflavone  |  BMS-813160  |  CCR7 Ligand 1  |  MK-0812 Succinate  |  K777  |  Vercirnon  |  DAPTA  |  Tivumecirnon  |  C-021  |  CCR2 antagonist 4 hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds