- ￥909 - 5863
- MedChemExpress(MCE)
- 美国
- HY-141449
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2763260-36-0
- 规格：
1 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥909.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2000.0 |
| 规格： | 10 mg | 产品价格： | ￥3500.0 |
| 规格： | 25 mg | 产品价格： | ￥5863.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
NRX-103094
CAS No. : 2763260-36-0
MCE 国际站：NRX-103094
产品活性：NRX-103094 是一种有效的 β-catenin 与 同源 E3 ligase SCFβ-TrCP 的相互作用增强剂，增强 pSer33/Ser37 β-catenin 与 β-TrCP 的结合，EC50 为 62 nM，Kd 为 0.6 nM。
研究领域：PROTAC | Stem Cell/Wnt
作用靶点：Molecular Glues | β-catenin
In Vitro: NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC50 of 457 nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250 nM.
NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5 μM in the absence of compound to 22 nM in the presence of 40 μM compound. In the presence of 20 μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20 μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein.
相关产品：Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Cytoskeleton Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Molecular Glue Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Laduviglusib | Cyclosporin A | XAV-939 | Lenalidomide | Pomalidomide | ICG-001 | CC-885 | Eragidomide | MSAB | SKL2001 | Iberdomide | Indisulam | 3-Indoleacetic acid | Thalidomide | Mezigdomide | Salinomycin | Tegatrabetan | LF3 | E7820 | BI-3802 | Toxoflavin | FH535 | Avadomide | PNU-74654 | TMX-4116 | ALV2 | Cardamonin
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
