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- PeproTech
- 300-09
- 美国
- 2025年12月11日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 供应商：
PeproTech(派普泰克)
- 英文名：
Recombinant Human MIP-1beta (CCL4)
| Synonyms : |
Macrophage Inflammatory Protein-1 beta, CCL4, ACT-2 |
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| Description : |
Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 betais a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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| Catalog #: |
300-09 |
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| Source : |
E.coli |
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| Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
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| Endotoxin Level : |
Endotoxin level is less than 0.1 ng per µg (1EU/µg). |
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| Biological Activity : |
Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml. |
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| Selected References : |
Selected List of References Citing This Product |
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| AA Sequence : |
APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN |
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| PubMed Link : |
MIP-1beta+AND+human |
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| Country of Origin : |
USA |
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文献和实验1 大鼠肝细胞的分离和培养 大鼠4％戊巴比妥麻醉，门静脉插管，先以无钙灌流液灌流，继以37℃通入O2的Ⅳ型胶原酶灌流液继续循环灌流15 min。将肝脏移至一平皿内，轻轻撕去肝包膜后，加入含5％小牛血清的清洗液，用吸管吹打成单个肝细胞悬液，200目尼龙网过滤，低速离心（500 r・min-1，1 min，4℃）弃上清，同法用清洗液反复洗3次。然后用完全1640培养液（内含10％小牛血清，105 U・L-1青霉素，100 mg・L-1链霉素和10 mg・L-1胰岛素）制成1×109个・L-
1 大鼠肝细胞的分离和培养 大鼠4％戊巴比妥麻醉，门静脉插管，先以无钙灌流液灌流，继以37℃通入O2的Ⅳ型胶原酶灌流液继续循环灌流15 min。将肝脏移至一平皿内，轻轻撕去肝包膜后，加入含5％小牛血清的清洗液，用吸管吹打成单个肝细胞悬液，200目尼龙网过滤，低速离心（500 r・min-1，1 min，4℃）弃上清，同法用清洗液反复洗3次。然后用完全1640培养液（内含10％小牛血清，105 U・L-1青霉素，100 mg・L-1链霉素和10 mg・L-1胰岛素）制成1×109个・L-
1 大鼠肝细胞的分离和培养 大鼠4％戊巴比妥麻醉，门静脉插管，先以无钙灌流液灌流，继以37℃通入O2的Ⅳ型胶原酶灌流液继续循环灌流15 min。将肝脏移至一平皿内，轻轻撕去肝包膜后，加入含5％小牛血清的清洗液，用吸管吹打成单个肝细胞悬液，200目尼龙网过滤，低速离心（500 r・min-1，1 min，4℃）弃上清，同法用清洗液反复洗3次。然后用完全1640培养液（内含10％小牛血清，105 U・L-1青霉素，100 mg・L-1链霉素和10 mg・L-1胰岛素）制成1×109个・L-
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