- 询价
- PeproTech
- 200-13A
- 美国
- 2025年12月29日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 供应商：
PeproTech(派普泰克)
- 库存：
大量
- 英文名：
Recombinant Human IL-13 Variant
| Synonyms : |
none. |
||||||||||||||||||||||||
| Description : |
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. 's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112. |
||||||||||||||||||||||||
| Catalog #: |
200-13A |
||||||||||||||||||||||||
| Source : |
E.coli |
||||||||||||||||||||||||
| Purity : |
Greater than 98% by SDS-PAGE gel and HPLC analyses. |
||||||||||||||||||||||||
| Endotoxin Level : |
Endotoxin level is less than 0.1 ng per µg (1EU/µg). |
||||||||||||||||||||||||
| Biological Activity : |
This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in-vitro dose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13, as measured by the induction of airway hyper-responsiveness. |
||||||||||||||||||||||||
| Selected References : |
Selected List of References Citing This Product |
||||||||||||||||||||||||
| AA Sequence : |
MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN |
||||||||||||||||||||||||
| PubMed Link : |
IL-13+gln+AND+arg+OR+arg110gln |
||||||||||||||||||||||||
| Country of Origin : |
USA |
||||||||||||||||||||||||
|
|
|||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||
|
|
|
||||||||||||||||||||||||
|
|
Special Sizes: |
||||||||||||||||||||||||
|
|
Usage: |
||||||||||||||||||||||||
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
- 作者
- 内容
- 询问日期
文献和实验枪的枪头轻吹几下，即可使细胞因子或重组蛋白完全溶解。 对于不易溶解的细胞因子或蛋白，PeproTech会在说明书中进行备注(Note)。如在重组人IL-13(产品编号：200-13)的说明书中您会看到：Slow to dissolve (缓慢溶解)，在重组人IL-11(产品编号：200-11)的说明中会看到： This solution is slow to dissolve.(该溶液溶解缓慢)。这种情况下，您最好能将要溶解的细胞因子或重组蛋白放在水平摇床(shaker)上低速摇一段
)，最终结果还是部分蛋白未溶解，导致蛋白活性的减弱。 3) 一定不能振荡(vortex)。 这里所说的振荡是指用涡旋仪进行快速振荡。 有用户会问，若想保证溶解液与冻干粉充分混匀，以实现细胞因子或重组蛋白的完全溶解，该怎么办呢？ 答：多数细胞因子或重组蛋白的冻干粉是非常容易溶解的，一般我们用移液枪的枪头轻吹几下，即可使细胞因子或重组蛋白完全溶解。 对于不易溶解的细胞因子或蛋白，PeproTech会在说明书中进行备注(Note)。如在重组人IL-13(产品
蛋白的完全溶解，该怎么办呢？ 答：多数细胞因子或重组蛋白的冻干粉是非常容易溶解的，一般我们用移液枪的枪头轻吹几下，即可使细胞因子或重组蛋白完全溶解。 对于不易溶解的细胞因子或蛋白，PeproTech会在说明书中进行备注(Note)。如在重组人IL-13(产品编号：200-13)的说明书中您会看到：Slow to dissolve (缓慢溶解)，在重组人IL-11(产品编号：200-11)的说明中会看到： This solution is slow to dissolve.(该溶液溶解缓慢
技术资料暂无技术资料 索取技术资料
