多巴胺受体D3抗体

英文名称Dopamine D3 receptor
中文名称多巴胺受体D3抗体
别 名DRD3; 3dopamine receptor; D; Dopamine receptor D3; DRD3; Dopamine receptor 3; ETM1; FET1; D(3) dopamine receptor; DRD3; DRD3_HUMAN. 说 明 书50ul 100ul 200ul
研究领域细胞生物 神经生物学 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
多巴胺受体D3抗体产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:200-800 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse DRD3:352-446/446 <Extracellular>
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). Also known as: dopamine D3 receptor; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1.

Subunit:
Interacts with CLIC6. Interacts with GRK4. Interacts with PALM.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Tissue Specificity:
Brain.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P30728

Gene ID:
13490

Database links:
Entrez Gene: 1814 Human
Entrez Gene: 13490 Mouse
Entrez Gene: 29238 Rat
Omim: 126451 Human
SwissProt: P35462 Human
SwissProt: P30728 Mouse
SwissProt: P19020 Rat
Unigene: 121478 Human
Unigene: 439735 Mouse
Unigene: 10356 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多巴胺受体D3常与某些精神、神经疾病有关，如精神分裂症、早发性痴呆等。但最新研究表明多巴胺受体与肿瘤细胞多药耐药有关。

Sample:
Brain (Mouse) Lysate at 40 ug
Brain (Rat) Lysate at 40 ug
Primary: Anti-Dopamine D3 receptor (bs-1743R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 44 kD
Observed band size: 48 kD