Capromorelin卡普瑞林酒石酸盐,193273-69

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Capromorelin Tartrate

CAS No. : 193273-69-7

MCE 国际站：Capromorelin Tartrate

产品活性：Capromorelin Tartrate 是一种可口服的，有效的growth hormone secretagogue receptor (GHSR)激动剂，对hGHS-R1a的K_i值为 7 nM。

研究领域：GPCR/G Protein

作用靶点：GHSR

In Vitro: Capromorelin stimulates GH release in rat pituitary cell cultures with EC₅₀ of 3 nM.

In Vivo: Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED₅₀ of 0.05 mg/kg iv.

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