- ￥990 - 2800
- MedChemExpress(MCE)
- 美国
- HY-100558
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
AI 赋能培养基定制开发：CHO 培养基是如何实现产量提升Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C, protect from light
- 英文名：
BafA1
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
88899-55-2
- 规格：
100 μg/500 μg/1 mg
| 规格： | 100 μg | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 500 μg | 产品价格： | ￥2050.0 |
| 规格： | 1 mg | 产品价格： | ￥2800.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Bafilomycin A1
CAS No. : 88899-55-2
MCE 国际站：Bafilomycin A1
产品活性：Bafilomycin A1 (BafA1) 是特异性，可逆的 V-ATPase 抑制剂，IC50 值为 4-400 nmol/mg。Bafilomycin A1，大环内酯类抗生素， 是一种自噬 (autophagy) 晚期阶段抑制剂。Bafilomycin A1 阻断自噬体与溶酶体的融合，并抑制培养细胞溶酶体中的酸化和蛋白质降解。Bafilomycin A1 也诱导调亡 (apoptosis)。
研究领域：Membrane Transporter/Ion Channel | Autophagy | Anti-infection | Apoptosis
作用靶点：Proton Pump | Autophagy | Antibiotic | Bacterial | Apoptosis
In Vitro: Bafilomycin A1 is treated to different types of membrane ATPases with the I50 of 400 nmol/mg, 4 nmol/mg and 50 nmol/mg for the vacuolar ATPases of a fungus (N. crassa), a plant (Z. mays), and an animal (bovine abrenal medulla). The I50 values refer as μmol of Bafilomycin A1 per mg of protein giving 50% inhibition of ATPase activity.
Bafilomycin A1 ((-)-Bafilomycin A1) disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion.
Bafilomycin A1 at a low concentration (1 nM) effectively and specifically inhibits and kills pediatric B-cell acute lymphoblastic leukemia cells. It targets both early and late stages of the autophagy pathway, mitochondria and induces caspase-independent apoptosis. Bafilomycin A1 induces the binding of Beclin 1 to Bcl-2, which further inhibits autophagy and promotes apoptotic cell death.
The growth of the BEL-7402 hepatocellular carcinoma and HO-8910 ovarian cancer cell lines are retarded and the metastatic potential is inhibited by Bafilomycin A1. Transmission electron microscopy and assays of capsase-3 and -9 suggest that Bafilomycin A1 induces apoptosis.
Bafilomycin A1 inhibits the growth of a variety of cultured cells dose-dependently, including golden hamster embryo and NIH-3T3 fibroblasts, whether or not they are transformed, and PC12 and HeLa cells. The IC50 of Bafilomycin A1 for inhibition of cell growth ranges from 10 to 50 nM.
In Vivo: Chronic treatment with low-dose Bafilomycin A1 (0.1 mg/kg) slightly inhibits the tumor volume, but the final tumor volume does not differ significantly from the control. However, chronic treatment with high dose Bafilomycin A1 (1 mg/kg) inhibits the tumor growth significantly, compared with controls, after 21 days.
Bafilomycin A1 (0.1 mg/kg or 1 mg/kg; i.p. daily for 3 days) extends the survival of B-cell acute lymphoblastic leukemia (B-ALL) xenograft mice with advanced disease.
相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Macrocyclic Compound Library | MG-132 | Rapamycin | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Dexamethasone | Acetylcysteine | Puromycin dihydrochloride | Angiotensin II human | Dimethyl sulfoxide | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | G-418 disulfate | Temozolomide | Rotenone | Mdivi-1 | Elesclomol
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验The Polymerase Chain Reaction (PCR)
purification issues. • Mullis properly exploited amplification.The Basics of PCR Cycling • 30–35 cycles each comprising: – denaturation (95°C),30 sec. – annealing (55–60°C),30 sec. – extension (72°C),time depends on product size. What’s in the Reaction?
【资源】Electrophoresis in Practice 4th edition
gradients 55 3.5.1 Free carrier ampholytes 55 3.5.2 Immobilized pH gradients 59 3.6 Protein detection in IEFgels 62 3.7 Preparative isoelectric focusing 62 3.8 Titration curve analysis 64 4 Blotting 67 4.1 Principle 67 4.2 Transfer methods 68 4.2
。尽管如此，约三分之一的SLC转运蛋白底物尚未被实验确定[4]，这些孤儿SLC的底物预测和功能鉴定仍是当前SLC研究的重点方向之一。 表1 重点SLC亚家族速览 亚家族 代表成员 主要转运底物 疾病/研究方向 SLC1 SLC1A2(EAAT2)、SLC1A3(EAAT1)、SLC1A5(ASCT2)、SLC1A6(EAAT4) 兴奋性氨基酸/中性氨基酸 肿瘤代谢、免疫治疗耐药、神经退行性疾病 SLC2 SLC2A1(GLUT1)、SLC
技术资料暂无技术资料 索取技术资料
