人 TERT 过表达慢病毒产品信息

人 TERT 过表达慢病毒产品信息

订购信息

货号	种属	载体	描述	荧光	价格	周期
HZ198253	Human	腺病毒	Homo sapiens telomerase reverse transcriptase (TERT，hTERT，TP2，TRT，EST2，TCS1，hEST2), transcript variant 1, mRNA NM_198253	无荧光	15000 14000	3-4 周

基本信息

基因名称：	TERT
NCBI序列号：	NM_198253
基因描述：	Homo sapiens telomerase reverse transcriptase (TERT，hTERT，TP2，TRT，EST2，TCS1，hEST2), transcript variant 1, mRNA NM_198253
基因种属：	Human
荧光标记：	无荧光
慢病毒滴度：	108 TU/ml

产品说明书

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基因简介

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.