Modecainide莫地卡尼,81329-71-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Modecainide

CAS No. : 81329-71-7

MCE 国际站：Modecainide

产品活性：Modecainide 是Encainide 的一种主要代谢物，Encainid 是一种抗心律失常活性分子。

研究领域：Metabolic Enzyme/Protease

作用靶点：Drug Metabolite

In Vivo: The effect of Encainide and its two major metabolites, O-demethylated Encainide (MJ 9444) and 3-O-methoxy Encainide (MJ 14030), on cardiac conduction is studied by recording His bundle potentials in isolated perfused rabbit hearts and Purkinje and muscle conduction in vivo in dog hearts after destruction of the atrioventricular node. Both metabolites are 4 to 15 times more potent than Encainide in slowing conduction through the atria, the AV-node and the His-Purkinje system of the rabbit heart. In the dog, Encainide (0.8-3.2 mg/kg i.v.) slows conduction of extrasystoles in both Purkinje and muscle at all coupling intervals, increases the effective refractory period and the functional refractory period of the Purkinje pathway. MJ 9444 (0.05-0.4 mg/kg) speeds Purkinje conduction of early (less than 300 msec) without affecting or while slowing conduction of late (greater than 350 msec) extrasystoles. Higher doses (0.4-1.6 mg/kg) slows conduction at all intervals. The effective refractory period and the functional refractory period are decreased but in some cases returned to control values at the higher doses. Muscle conduction is slowed at doses of 0.4 mg/kg or more. MJ 14030 (0.05-3.2 mg/kg) has variable effects, behaving like MJ 9444 in three experiments but like the parent compound in two others.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Drug Metabolite Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Clozapine N-oxide  |  Oseltamivir acid  |  Urolithin A  |  Phosphoramide mustard cyclohexanamine  |  Teriflunomide  |  Mycophenolate Mofetil  |  Gemfibrozil 1-O-β-glucuronide  |  VRT-043198  |  GS-443902 trisodium  |  4-Hydroperoxy cyclophosphamide  |  Monomethyl fumarate  |  Penicillamine  |  Nortriptyline hydrochloride  |  4-Hydroxymephenytoin  |  Linsidomine hydrochloride  |  Pyocyanin  |  MTIC  |  Ercalcitriol  |  Endoxifen hydrochloride  |  N-Deshydroxyethyl Dasatinib  |  Abemaciclib metabolite M2  |  Deslanoside  |  Palifosfamide  |  Thyroxine sulfate  |  Monobutyl phthalate  |  N-Desmethyl imatinib  |  AR-13503  |  Hydroxy Itraconazole  |  N-Desethyl Sunitinib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds