- ￥500 - 3200
- MedChemExpress(MCE)
- 美国
- HY-101298
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
57046-73-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥700.0 |
| 规格： | 25 mg | 产品价格： | ￥1200.0 |
| 规格： | 50 mg | 产品价格： | ￥2100.0 |
| 规格： | 100 mg | 产品价格： | ￥3200.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Paprotrain
CAS No. : 57046-73-8
MCE 国际站：Paprotrain
产品活性：Paprotrain是可渗透细胞的kinesin MKLP-2 的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC50 值为 1.35 μM，Ki 值为 3.36 μM，同时对 DYRK1A 有中等的抑制作用，IC50值为 5.5 μM。
研究领域：Cell Cycle/DNA Damage | Cytoskeleton
作用靶点：Kinesin
In Vitro: Paprotrain has been screened on a panel of CNS kinases. While inactive (IC50 >10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC50=5.5 μM). Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.
相关产品：Covalent Screening Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Cytoskeleton Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Pain-Related Compound Library | Cysteine Targeted Covalent Library | Highly Selective Inhibitors Library | Ispinesib | Filanesib | GSK-923295 | AZ82 | Monastrol | SB-743921 hydrochloride | Litronesib | S-Trityl-L-cysteine | GW406108X | Kif15-IN-1 | CW-069 | EMD534085 | Dimethylenastron | PF-2771 | ARQ 621 | K858 (Racemic) | BRD9876 | Kif15-IN-2 | PVZB1194 | Eg5 Inhibitor V, trans-24 | MK-0731 | AZD4877 | Eg5-IN-1 | Kolavenic acid analog | KSP-IA
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
