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- 详细信息
- 技术资料
- 保存条件：
低温
- 英文名：
L-Mimosine from Koa hoale seeds
- 库存：
现货
- 供应商：
上海善然生物科技有限公司
- CAS号：
500-44-7
产品名称
包装
1 g in glass bottle
100, 500 mg in glass bottle
25 mg in poly bottle
Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. An iron chelator that inhibits DNA replication in mammalian cells. Has been shown to have apoptotic activity in xenotransplanted human pancreatic cancer. L-Mimosine is also used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). L-Mimosine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC 1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
性质
Related Categories Apoptosis and Cell Cycle, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, DNA Synthesis and Repair, HIF 脯氨酸羟化酶抑制剂,
更多...
InChI Key WZNJWVWKTVETCG-YFKPBYRVSA-N
assay ≥98%
包装
1 g in glass bottle
100, 500 mg in glass bottle
25 mg in poly bottle
Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. An iron chelator that inhibits DNA replication in mammalian cells. Has been shown to have apoptotic activity in xenotransplanted human pancreatic cancer. L-Mimosine is also used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). L-Mimosine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity.
Features and Benefits
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC 1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
性质
Related Categories Apoptosis and Cell Cycle, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, DNA Synthesis and Repair, HIF 脯氨酸羟化酶抑制剂,
更多...
InChI Key WZNJWVWKTVETCG-YFKPBYRVSA-N
assay ≥98%
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L-Mimosine from Koa hoale seeds 从膝关节骨性关节炎的hoale种子含羞草碱
¥270
