相关产品推荐更多 >

tar抗体tar兔多抗抗体Aspartate chemoreceptor protein antibody抗体tar Antibody, HRP conjugated抗体
¥880
UBE4A抗体UBE4A一抗抗体UFD2b antibody抗体UBE4A Antibody抗体
¥880
CDC37L1抗体CDC37L1一抗抗体RP11-6J24.5 antibody抗体CDC37L1 Antibody抗体
¥1100
MMP9抗体MMP9一抗抗体Type V collagenase antibody抗体MMP9 Antibody抗体
¥880
NPY4R抗体NPY4R兔多抗抗体PP1抗体NPY4R Antibody, Biotin conjugated抗体
¥880
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthetic methylated peptide corresponding to residues surrounding Arg26 of Human histone H3
- 亚型:
/
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
Polyclonal
- 标记物:
/
- 适应物种:
Human,Mouse,Rat
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q16695
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
ELISA,WB,IF;WB:1:500-1:2000,IF:1:50-1:200
- 浓度:
>95%,Antigen Affinity Purified
- 靶点:
HIST3H3
- 抗体英文名:
Histone H3R26me2s Antibody
- 抗体名:
/
- 规格:
100μl
保存缓冲液
/功能
Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4,7). Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms (2,3). Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis (8-10). Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase (11).
风险提示:丁香通仅作为第三方平台,为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全,合理判断,谨慎选购商品,商家和用户对交易行为负责。对于医疗器械类产品,请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验三句话读懂一篇 CNS,酗酒背后的机制,环境-基因互作诱导肿瘤发生,Cas9 时钟...
大学、阿卜杜拉国王科技大学以及澳门大学的研究人员联合在 Nature 杂志发表论文 Elevated NSD3 histone methylation activity drives squamous cell lung cancer,研究揭示 组蛋白 H3 赖氨酸 36(H3K36) 甲基转移酶 NSD3(其基因位于 8p11-12 扩增子中) 是肺鳞癌(LUSC)肿瘤发生的关键调控因子。体外、体内实验及结构动力学实验表明 H3K36(H3K36me2)的二甲基化显示出增加的催化活性,即 NSD3(T
, T. D., Henikoff, J. G., ... & Henikoff, S. (2019). CUT&Tag for efficient epigenomic profiling of small samples and single cells. Nature communications, 10(1), 1930. [5] Wang, Q., Xioong, H., Ai, S., Yu, X., Liu, Y., Zhang, J., & He, A. (2019
浅析染色质免疫沉淀(ChIP)技术在 DNA 与蛋白质相互作用研究中的重要性
。结果显示 GSTP1 基因在处理组和非处理组之间有显著差异,这表明 Se 处理的癌细胞 GSTP1 启动子相关的 H3-K9 乙酰化水平提高、 H3-K3 甲基化水平降低,预示 Se 可能具有调节染色质表观结构的功能。 正因为 ChIP 技术对于表观遗传学及信号转导研究是如此之重要,默克密理博特别为该领域的科学家们专门开发了的 ChIP 解决方案,其中完备的 ChIP 试剂盒免去提前准备各种试剂(包括鲑鱼精子 DNA 包被的琼脂糖珠子、Protein A/G 等)的麻烦,专用的 ChIP 抗体
技术资料暂无技术资料 索取技术资料





