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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Synthesized peptide derived from Human MDC1 around the phosphorylation site of S513.
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性:
/
- 标记物:
Non-conjugated
- 适应物种:
Human
- 保质期:
6个月
- 抗原来源:
Homo sapiens (Human)
- 目录编号:
Q14676
- 级别:
优
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 宿主:
Rabbit
- 应用范围:
IHC, ELISA; IHC:1:100-1:300, ELISA:1:5000
- 浓度:
>95%,The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 靶点:
MDC1
- 抗体英文名:
Phospho-MDC1 (S513) Antibody
- 抗体名:
Nuclear Factor with BRCT Domains Protein 1 antibody
- 规格:
100μg/50μg
| 规格: | 100μg | 产品价格: | ¥1320.0 |
|---|---|---|---|
| 规格: | 50μg | 产品价格: | ¥880.0 |
保存缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.功能
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文献和实验【求助】E.coli修复DSB损伤与真核DSB方式有何不同?
nuclear factor family)成员确认为是DDR蛋白,它与γH2AX和MDC1一起发挥作用,应对细胞内出现的DSB。RNF8 包含一个 FHA 结构域,该结构域能和磷酸基苏氨酸(phospho-Thr)结合;RNF8的环指结构(RING finger)能与E3泛素连接酶作用。RNF8通过FHA结构域与 MDC1结合,不过这种结合作用依赖于MDC1的磷酸化作用。三个研究小组都一致发现在细胞发生DNA双链断裂现象时MDC1 会磷酸化,并对此做出应答。Kolas等人研究发现毛细血管扩张性共济失调突变
, Hedgehog, and insulin pathways, as well as the activationof nuclear factor (NF)-kB-mediated gene transcription. These signaling pathways regulate gene transcription,cell cycle, apoptosis, inflammation, glucose metabolism, stem-cell renewal
Identification of a Mutant Kinase/ATP Analog Pair
to the epitope tag on the protein kinase of interest A phospho-specific antibody to a known substrate of your kinase (if available) Gels SDS-PAGE gel Special
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