PPARg2 质粒

PPAR-γ2

名称: 过氧化物酶体增殖因子活化受体γ

描述: Peroxisome proliferators are non genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. The PPAR gamma 2 isoform appears to be induced very early in the differentiation of several cultured adipocyte cell lines, and has been suggested to be a dominant regulator of the murine P2 (aP2) gene which encodes an intracellular lipid binding protein which is expressed only in adipose cells. PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with RXR alpha. Defects in PPAR gamma can lead to type 2 insulin-resistant diabetes and hyptertension and could play a role in the genetic predisposition to obesity

过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor, PPAR)是调节目标基因表达的核内受体转录因子超家族成员， 1990 年Issemann 等首先发现了这种能被一类脂肪酸样化合物过氧化物酶体增殖剂(peroxisome proliferators, PP) 激活, 而被命名为PP 激活受体( peroxisome proliferator activated receptor, PPAR)。根据结构的不同，PPAR可分为α、β(或δ)和γ三种类型，其中PPARγ主要表达于脂肪组织及免疫系统，与脂肪细胞分化、机体免疫及胰岛素抵抗关系密切，是胰岛素增敏剂噻唑烷二酮类药物(troglitazone, TZDs)作用的靶分子，成为近年来研究热点。