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- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-16269R |
| 英文名称 | GPCR MRGE/GPCR GPR167 Rabbit pAb |
| 中文名称 | G蛋白偶联受体167抗体 |
| 英文别名 | G protein coupled receptor 167; G-protein coupled receptor 167; GPR167; Mas related G protein coupled MRGE; MAS related GPR member E; Mas-related G-protein coupled receptor member E; MRGE; MRGPRE; MRGRE_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GPCR MRGE/GPCR GPR167 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 34 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Cell membrane. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. Mas subfamily. |
| 功能 | Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MRGE is a 311 amino acid multi-pass membrane protein that acts as an orphan receptor and is though to influence nociceptor function. A member of the G-protein coupled receptor 1 family and MAS subfamily, MRGE is encoded by a gene that maps to human chromosome 11p15.4 and mouse chromosome 7 F5. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验Nature！中美学者共同破译粘附类 GPCR 自激活机制之谜
activation of adhesion GPCRs 工作中，研究者们回答了这一未解谜题。 孙金鹏教授团队解析了粘附类受体 GPR133 和 GPR114 结构，发现 GPR133 GPS 位点发生水解，在质膜上发生 NTF-CTF 分离，GPR114 不发生自水解，能够感知机械力。通过功能实验证明了受体感知机械力后通过 Stachel 序列激活受体，并确定 Stachel 中的 5 个疏水氨基酸组成的保守 HIM（Fss-03xφφφxφss-09），其在 Stachel 序列与受体相互作用中起着核心
同日 4 篇 Nature！中美学者共同破译粘附类 GPCR 自激活机制之谜
水解，在质膜上发生 NTF-CTF 分离，GPR114 不发生自水解，能够感知机械力。通过功能实验证明了受体感知机械力后通过 Stachel 序列激活受体，并确定 Stachel 中的 5 个疏水氨基酸组成的保守 HIM（Fss-03xφφφxφss-09），其在 Stachel 序列与受体相互作用中起着核心作用，对 Stachel 序列介导的粘附类受体机制有了深入了解。同时为 Stachel 序列外源短肽设计提供了依据，为靶向粘附类受体相关疾病的鉴定和治疗奠定了基础。 图 3：GPR133-CTF–
genome genetic and physical map data 78. IXDB http://ixdb.mpimg-berlin-dahlem.mpg.de/ Physical maps of human chromosome X 79. RHdb http://www.ebi.ac.uk/RHdb Radiation hybrid map data 80. The Unified Database http://bioinfo.weizmann.ac.il/udb
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