Sample:
_x000D_
Lane 1: HL60 (Human) Cell Lysate at 30 ug
_x000D_
Lane 2: Skin (Mouse) Lysate at 40 ug
_x000D_
Primary:
_x000D_
Anti-phospho-CXCR2 (Ser347) (bs-12257R) at 1/1000 dilution
_x000D_
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_
Predicted band size: 45/55 kD
_x000D_
Observed band size: 48 kD
- ￥1180 - 2800
- Bioss
- bs-12257R
- 2026年10月14日
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-12257R |
| 英文名称 | phospho-CXCR2 (Ser347) Rabbit pAb |
| 中文名称 | 磷酸化细胞表面趋化因子受体2抗体 |
| 英文别名 | CXCR2(phospho S347); CXCR2(phospho Ser347); p-CXCR2(phospho S347); p-CD182(phospho Ser347); CXC-chemokine receptor 2; CD 182; CD182; CD182 antigen; CDw128b; Chemokine(CXC) receptor 2; CMKAR2; CXCR 2; CXC R2; CXC-R2; CXCR2_HUMAN; C-X-C chemokine receptor type 2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Dog, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser347 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 41 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Other cell division antibodies Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 翻译后修饰 | Phosphorylated upon ligand binding; which is required for desensitization. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
_x000D_ Bone (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti-phospho-CXCR2 (Ser347) (bs-12257R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 41 kD
_x000D_ Observed band size: 51 kD
_x000D_
_x000D_ Bone (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti-phospho-CXCR2 (Ser347) (bs-12257R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 41 kD
_x000D_ Observed band size: 51 kD
_x000D_
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CXCR2 | IL8RA/CD181 (p-S347) Rabbit pAb(bs-12257R)-50ul/100ul/200ul
￥1180 - 2800
