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- 2025年10月16日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-3800R |
| 英文名称 | Ig kappa chain C region Rabbit pAb |
| 中文名称 | k轻链抗体 |
| 英文别名 | Kappa Light Chain; IGKC; HCAK 1; HCAK1; Ig kappa chain C region; IGKC; Immunoglobulin kappa constant; Immunoglobulin kappa constant region; Immunoglobulin kappa light chain; Kappa 1 immunoglobulin light chain; Km; MGC111575; MGC62011; MGC72072; MGC88770; MGC88771; MGC88809; Human Ig/L-Chain Kappa; IGKC_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human) |
| 抗体来源 | Rabbit |
| 免疫原 | Purified human Kappa light chain |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 11 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Light Chain > Kappa |
| 亚细胞定位 | Cytoplasmic and Secreted. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 8.408 }}] {Hu Xi′e. et al. Clinical and biological heterogeneities in triple-negative breast cancer reveals a non-negligible role of HER2-low. BREAST CANCER RES. 2023 Dec;25(1):1-22} {IF} {Human}
[IF={{ 2.86 }}] {Shen, Liming, et al. "Redox Proteomic Profiling of Specifically Carbonylated Proteins in the Serum of Triple Transgenic Alzheimer’s Disease Mice."International Journal of Molecular Sciences 17.4 (2016): 469.} {WB} {="Mouse"}
[IF={{ 13.116 }}] {Zhengnan Yang. et al. Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs. Sci Adv. 2021 Feb;7(9):eabb0737} {IF} {Human}
对IgG 的化学结构提出了一个模式图 （图38 －1），后经许多学者证实，其他几类Ig具有与IgG 相似的基本结构。 一、四肽链结构 所有Ig 的基本单位都是四肽链的对称结构，其中二条为相同的重链 （heavy chain ， H 链），其分子量较大，由440 个氨基酸组成，另二条为相同的轻链 （light chain ，L 链） 其分子量较小，只含214 个氨基酸。重链上结合有不同量的糖，故Ig 属糖蛋白。轻链根据其C 区的化学结构和抗原性的差异分为κ（Kappa） 和λ（Lambda
Antigen Design Sera Purification Tech Sheet
domain then the choice is simple. For example, if one is studying proteolytic processing of an N-terminal precursor, antibodies against the N-terminal region of interest would be raised. Likewise if the goal is to monitor the phosphorylation state
为氨基端（N端）和羧基端（C端）。 （一）轻链和重链 由于骨髓瘤蛋白（M蛋白）是均一性球蛋白分子，并证明本周蛋白（BJ）是Ig分子的L链，很容易从患者血液和尿液中分离纯化这种蛋白，并可对来自不同患者的标本进行比较分析，从而为Ig分子氨基酸序列分析提供了良好的材料。 1．轻链（light chain,L） 轻链大约由214个氨基酸残基组成，通常不含碳水化合物，分子量约为24kD。每条轻链含有两个由链内二硫键内二硫所组成的环肽。L链共有两型：kappa(κ)与lambda
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