WISP2 Rabbit pAb(bs-5100R)-50ul/100ul/200ul
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WISP2 Rabbit pAb(bs-5100R)-50u

l/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-5100R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-5100R
    英文名称WISP2 Rabbit pAb
    中文名称Wnt1诱导信号通路蛋白2抗体
    英文别名CTGFL; CCN family member 5; CCN5; Connective tissue growth factor like protein; Connective tissue growth factor related protein 58; Connective tissue growth factor-like protein; Connective tissue growth factor-related protein 58; CT58; CTGF L; CTGFL; CTGF-L; WISP 2; WISP-2; Wisp2; WISP2_HUMAN; WNT1 inducible signaling pathway protein 2; WNT1-inducible-signaling pathway protein 2.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat, Pig, Cow, Rabbit, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CTGFL
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量24 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Secreted
    亚细胞定位Secreted.
    组织特异性Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.
    相似性Belongs to the CCN family.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 TSP type-1 domain.
    Contains 1 VWFC domain.
    功能May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料WISP2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. WISP2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    WISP2 Rabbit pAb(bs-5100R)-50u
    P‌‌araformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (WISP2) Polyclonal Antibody, Unconjugated (bs-5100R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    WISP2 Rabbit pAb(bs-5100R)-50u
    Sample: A431 Cell (Human) Lysate at 40 ug
    Primary: Anti-WISP2 (bs-5100R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 24 kD
    Observed band size: 24 kD
    WISP2 Rabbit pAb(bs-5100R)-50u
    Sample: A549 Cell (Human) Lysate at 40 ug
    Primary: Anti-WISP2 (bs-5100R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 24 kD
    Observed band size: 24 kD

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    图标文献和实验
    该产品被引用文献

    [IF={{ 5.782 }}] {Zolfaghari, Sima. et al. Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction. 2021 Dec 01} {IHC} {Mouse}

    [IF={{ 2.127 }}] {Sun S et al. CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells. Cell Biol Int. 2019 Dec 30.} {WB} {Human}

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    文献支持
    WISP2 Rabbit pAb(bs-5100R)-50ul/100ul/200ul
    ￥1180 - 2800