Blank control(blue): RAJI(fixed with 2% Paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti-Phospho-PLC beta3 (Ser1105) antibody(bs-3341R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
- ￥1180 - 2800
- Bioss
- bs-3341R
- 2026年10月14日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-3341R |
| 英文名称 | phospho-PLCB3 (Ser1105) Rabbit pAb |
| 中文名称 | 磷酸化磷酯酶Cβ3抗体 |
| 英文别名 | PLCB3_HUMAN; 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3; 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3; EC:3.1.4.11; phosphoinositide phospholipase C-beta-3; phospholipase C-beta-3(PLC-beta-3); SMDCD; phospholipase C beta 3; |
| 产品应用 | ICC/IF=1:100-500, Flow-Cyt=1μg /Test Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Pig, Cow, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human PLC beta3 around the phosphorylation site of Ser1105 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 136 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Signaling Pathway > Lipid Signaling > PLC |
| 亚基 | Interacts with SHANK2. Interacts with LPAR2. |
| 亚细胞定位 | Membrane; Peripheral membrane protein. |
| 相似性 | Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. |
| 功能 | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
| {Flow-Cyt} | {1μg /Test} |
MCF-7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (Phospho-PLC beta3 (Ser1105) ) polyclonal Antibody, Unconjugated (bs-3341R) 1:50, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.
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文献和实验该产品被引用文献
[IF=16.6] Ding Yangyang. et al. MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis. NAT COMMUN. 2023 Aug;14(1):1-15 WB Mouse
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PLCB3 | PLC-beta-3 (p-S1105) Rabbit pAb(bs-3341R)-50ul/100ul/200ul
￥1180 - 2800
