Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Large intestine tissue lysates
Lane 3: Mouse Placenta tissue lysates
Lane 4: Mouse Liver tissue lysates
Lane 5: Mouse Lung tissue lysates
Lane 6: Rat Cerebrum tissue lysates
Lane 7: Rat Large intestine tissue lysates
Lane 8: Rat Placenta tissue lysates
Lane 9: Rat Liver tissue lysates
Lane 10: Rat Lung tissue lysates
Primary: Anti-RSPO2 (bs-18876R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 26 kDa
Observed band size: 28 kDa
- ￥1180 - 2800
- Bioss
- bs-18876R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-18876R |
| 英文名称 | RSPO2 Rabbit pAb |
| 中文名称 | RSPO2蛋白抗体 |
| 英文别名 | CRISTIN2; hRspo2; RSPO2_HUMAN; R spondin 2; R spondin 2 homolog; R-spondin 2 homolog(Xenopus laevis); R-spondin family, member 2; Roof plate-specific spondin-2. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse, Rat (Human, Dog, Pig, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human RSPO2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 26 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with WNT1. Binds heparin By similarity. Interacts with LGR4, LGR5 and LGR6. |
| 亚细胞定位 | Secreted |
| 相似性 | Belongs to the R-spondin family. Contains 1 FU (furin-like) repeat. Contains 1 TSP type-1 domain. |
| 功能 | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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RSPO2 Rabbit pAb(bs-18876R)-50ul/100ul/200ul
￥1180 - 2800
