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PRDM1 Rabbit pAb(bs-6466R)-50u

l/100ul/200ul
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  • ¥1180 - 2800
  • Bioss已认证
  • bs-6466R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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    • 规格

      50ul/100ul/200ul

    规格:50ul产品价格:¥1180.0
    规格:100ul产品价格:¥1980.0
    规格:200ul产品价格:¥2800.0
    产品编号bs-6466R
    英文名称PRDM1 Rabbit pAb
    中文名称PRDM1抗体
    英文别名PRDM1_HUMAN; PR domain zinc finger protein 1; BLIMP1; EC:2.1.1.-; BLIMP-1; BLIMP1; beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1(PRDI-BF1; PRDI-binding factor 1); PR/SET domain 1; PRDI-BF1;
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse (Human, Rat, Chicken, Pig, Cow, Horse, Rabbit)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PRDM1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量92 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation > Arginine Methylation

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger

    Immunology > Immune System Diseases > Antiviral Signaling

    Immunology > Immunoglobulins > Class Switching

    Immunology > Innate Immunity > Cytokines > Interferons

    亚基Interacts with PRMT5.
    亚细胞定位Nucleus. Cytoplasm.
    相似性Contains 4 C2H2-type zinc fingers.
    Contains 1 SET domain.
    功能Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:50-200}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded (mouse lymphoid tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRDM1) Polyclonal Antibody, Unconjugated (bs-6466R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    图标文献和实验
    该产品被引用文献

    [IF={{ 3.448 }}] {Ma Q et al. Non‐coenzyme role of vitamin B1 in RANKL‐induced osteoclastogenesis and ovariectomy induced osteoporosis. J Cell Biochem. 2020 Feb 26.} {WB} {mouse}

    [IF={{ 3.266 }}] {Ma Q et al. Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation. Am J Transl Res. 2019 Aug 15;11(8):5008-5018. eCollection 2019.} {WB} {Mouse}

    [IF={{ 2.416 }}] {Lu, Yinglin. et al. Ascorbic acid and all-trans retinoic acid promote proliferation of chicken blastoderm cells (cBCs) by mediating DNA demethylation. In Vitro Cell Dev-An. 2022 Mar;:1-11} {IF} {Chicken}

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    文献支持
    PRDM1 Rabbit pAb(bs-6466R)-50ul/100ul/200ul
    ¥1180 - 2800