Sample:
_x000D_
Raji (Human)Cell Lysate at 40 ug
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Hela (Human) Cell Lysate at 40 ug
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HepG2 (Human) Cell Lysate at 40 ug
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Primary: Anti-INPP5B(bs-16671R)at 1/300 dilution
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Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
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Predicted band size: 112kD
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Observed band size: 112kD
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- ￥1180 - 2800
- Bioss
- bs-16671R
- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-16671R |
| 英文名称 | INPP5B Rabbit pAb |
| 中文名称 | 聚磷酸肌醇磷酸酶5B抗体 |
| 英文别名 | 5-trisphosphate 5-phosphatase; 5PTase; 75 kDa inositol polyphosphate 5 phosphatase; 75 kDa inositol polyphosphate-5-phosphatase; 75kDa; EC 3.1.3.36; I5P2_HUMAN; Inositol polyphosphate 5-phosphatase II; Inositol polyphosphate-5-phosphatase B; Inositol polyphosphate-5-phosphatase, 75kDa; INPP5B; INPP5b protein; INPP5P; MGC65156; MGC71303; OTTHUMP00000004726; OTTHUMP00000004727; OTTHUMP00000004728; phosphoinositide 5 phosphatase; phosphoinositide 5-phosphatase; Type II inositol 1, 4, 5 trisphosphate 5 phosphatase; Type II inositol-1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human INPP5B |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 112 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation Signal Transduction > Signaling Pathway > Lipid Signaling > Lipid Phosphatases |
| 亚基 | Interacts with APPL1, FAM109A and FAM109B. Interacts with several Rab GTPases, at least RAB1A, RAB2A, RAB5A, RAB6A, RAB8A, RAB9A and RAB33B; these interactions may play a dual role in targeting INPP5B to the specific membranes and stimulating the phosphatase activity. {ECO:0000269|PubMed:17956944, ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288, ECO:0000269|Ref.10}. |
| 亚细胞定位 | Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Golgi apparatus. |
| 组织特异性 | Platelets. |
| 翻译后修饰 | Isoprenylation at Cys-990 may be required for localization at the membrane. {ECO:0000269|PubMed:7721860}. May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form. {ECO:0000269|PubMed:1718960}._x000D_ |
| 相似性 | Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family. Contains 1 Rho-GAP domain. |
| 功能 | Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269|PubMed:7721860}. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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INPP5B Rabbit pAb(bs-16671R)-50ul/100ul/200ul
￥1180 - 2800
